
Dr Ling-Shan Yu 余靈珊
Current
國立中山大學生技醫藥研究所 助理教授
兼任學士後醫學系 助理教授
Assistant Professor
Institute of BioPharmaceutical Sciences
College of Medicine
National Sun Yat-sen University
Taiwan
學經歷
2016-2019 英國帝國理工學院 電機學系 博士後研究員
Postgraduate researcher, Dept. of Electrical and Electronic Engineering, Imperial College London, London
2012-2016 英國帝國理工學院 生命科學系 博士
PhD, Dept. of Life Science, Imperial College London, London
2010-2011 英國帝國理工學院 生命科學系 碩士
MSc, Dept. of Life Science, Imperial College London, London
Publication (2018-now, SCI journal)
1. Jing-Wen Guo, Hsin-Ying Ho, Chia-Yen Dai, Yen-Hsu Chen, Ming-Lung Yu, Ling-Shan Yu* (2024) Single-Tube, Single-Strip Lateral-Flow Assays Utilizing Loop-Mediated Isothermal Amplification for Simultaneous Hepatitis B and C Viral Detection. Journal of Medical Virology, 96(6), e29721. (Virology = 4/41, Q1) (SCI, impact factor = 6.8)(corresponding author)
2. Hsin-Ying Ho, Wei-Sin Kao, Piyush Deval, Chia-Yen Dai, Yen-Hsu Chen, Ming-Lung Yu, Che-Hsin Lin, Ling-Shan Yu* (2023). Rapid and sensitive LAMP/CRISPR-powered diagnostics to detect different hepatitis C virus genotypes using an ITO-based EG-FET biosensing platform. Sensors and Actuators: B. Chemical, 394, 134278. (Instruments & Instrumentation = 1/76, Chemistry, Analytical = 5/106, Q1) (SCI, impact factor = 8.4). (corresponding author)
3. Wei-Sin Kao, Ling-Shan Yu, Che-Hsin Lin. (2023). Rapid Fluorescence-free Detection of DNA Loop-mediated Isothermal Amplification on Bare ITO Surface Under EG-FET Scheme. IEEE Sensors Journal, 23(13), 13876-13881. (Instruments & Instrumentation = 15/63, Q1) (SCI, impact factor = 4.3).
4. Chia-Hsu Hsieh, Chih-Hsien Huang, Jia-Huei Lin, Ling-Shan Yu, and I-Yu Huang (2023). Development of an EGFET microsensor with 3D structure for high-specificity cardiac troponin I detection. Journal of Micromechanics and Microengineering, 33(4), 045001. (Engineering electrical & electronic = 162/275) (SCI, impact factor = 2.3). (co-corresponding author)
5. Yu-Yao Chiu, Chun-Yu Lin, Ling-Shan Yu, Wen-Hung Wang, Chung-Hao Huang, Yen-Hsu Chen (2023). The association of obesity and dengue severity in hospitalized adult patients. Journal of Microbiology, Immunology and Infection, 56(2), 267-273. (Immunology = 34/161, Infectious diseases = 16/96, Q1) (SCI, impact factor = 7.4).
6. Nicolas Moser*, Ling-Shan Yu*, Jesus Rodriguez-Manzano, Kenny Malpartida-Cardenas, Anselm Au, Paul Arkell, Chiara Cicatiello, Ahmad Moniri, Luca Miglietta, Wen-Hung Wang, Sheng-Feng Wang, Alison Holmes, Yen-Hsu Chen and Pantelis Georgiou. (2022). Quantitative detection of dengue serotypes using a smartphone-connected handheld lab-on-chip platform. Frontiers in Bioengineering and Biotechnology, 10, 892853. (Multidisciplinary sciences = 16/73, Q1) (SCI, impact factor = 5.7). (co-1st author)
7. Ling-Shan Yu*, Sheng-Yeh Chou, Hsing-Yu Wu, Yu-Cheng Chen, Yen-Hsu Chen (2021). Rapid and semi-quantitative colorimetric loop-mediated isothermal amplification detection of ASFV via HSV color model transformation. Journal of Microbiology, Immunology and Infection, 54(5), 963-970. (Immunology = 34/161, Infectious diseases = 16/96, Q1) (SCI, impact factor = 7.4). (corresponding author & first author)
8. Ling-Shan Yu, Jesus Rodriguez-Manzano, Nicolas Moser, Kenny Malpartida Cardenas, Nicholas Miscourides, Thomas Sewell, Tatiana Kochina, Matthew C. Fisher and Pantelis Georgiou. (2020). Rapid detection of azole-resistant Aspergillus fumigatus in clinical and environmental isolates by use of a lab-on-a-chip diagnostic system. Journal of Clinical Microbiology, 58(11), 10-1128. (Microbiology = 17/135, Q1) (SCI, impact factor = 9.4). (first author)
9. M. Kalofonou, K M-Cardenas, G. Alexandrou, J. R-Manzano, Ling-Shan Yu, N. Moser, Allsopp, R. L.T. K. Gleason, K. Goddard, D. Fernandez-Garcia, K. Page, P. Georgiou, S. Ali, R. Coombes, J. Shaw, C. Toumazou (2020). A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p. H1047R breast cancer mutation. Scientific reports, 10(1), 4553. (Multidisciplinary Sciences = 22/73, Q2) (SCI, impact factor = 4.6).
10. Kai-Hong Tu*, Ling-Shan Yu*, Zong-Han Sie, Han-Yi Hsu, Khuloud T Al-Jamal, Julie Tzu-Wen Wang, Ya-Yu Chiang (2020). Development of real-time transendothelial electrical resistance monitoring for an in vitro blood-brain barrier system. Micromachines, 12(1), 37. (Chemistry, Analytical = 29/86, Q2) (SCI, impact factor = 3.4). (co-1st author)
11. Ling-Shan Yu, Jesus R-Manzano, Kenny M-Cardenas, Thomas Sewell, Oliver Bader, Darius Armstrong-James, Matthew C.Fisher and Pantelis Georgiou (2019). Rapid and sensitive detection of azole-resistant Aspergillus fumigatus by tandem repeat loop-mediated isothermal amplification. The Journal of Molecular Diagnostics, 21(2), 286-295. (Pathology = 8/87, Q1) (SCI, impact factor = 4.1). (first author)
12. K. M-Cardenas, N. Miscourides, J. R-Manzano, Ling-Shan Yu, J. Baum and P. Georgiou (2019). Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform. Biosensors and Bioelectronics, 145, 111678. (Biotechnology & applied microbiology = 7/158, Q1) (SCI, impact factor = 12.6).
13. Ahmad M.,Jesus R. M., Kenny M.C., Ling-Shan Yu, Xavier Didelot, Alison Holmes, Pantelis Georgiou (2019). Framework for dna quantification and outlier detection using multidimensional standard curves. Analytical chemistry, 91(11), 7426-7434. (Chemistry, analytical = 7/86, Q1) (SCI, impact factor = 7.4).
14. Nicholas Miscourides, Ling-Shan Yu, Jesus Rodriguez-Manzano and Pantelis Georgiou (2018). A 12.8 k current-mode velocity-saturation ISFET array for on-chip real-time DNA detection. IEEE transactions on biomedical circuits and systems, 12(5), 1202-1214. (Engineering, electrical & electronic = 68/275, Q1) (SCI, impact factor = 5.1).
15. K. M-Cardenas, J. R-Manzano, Ling-Shan Yu, Michael Delves, Chea Nguon, Kesinee Chotivanich, Jake Baum, Georgiou Pantelis (2018). Allele-specific isothermal amplification method using unmodified self-stabilizing competitive primers. Analytical chemistry, 90(20), 11972-11980. (Chemistry, analytical = 7/86, Q1) (SCI, impact factor = 7.4).
16. Ling-Shan Yu, Nicolas Moser, Jesus Rodriguez-Manzano, Sheng-Fan Wang, Yen-Hsu Chen, Alison Holmes and Pantelis Georgiou (2018). Engineering rapid and sensitive electronic diagnostics for dengue and Zika viruses. International Journal of Infectious Diseases, 73, 166. (Infectious diseases = 13/96, Q1) (SCI, impact factor = 8.4). (first author)
17. C-Sheng Lin, Duncan W. E. Allsopp, Kate Cavanagh, Hei Chit Leo Tsui, Ling-Shan Yu, Wang-Nan Wang, Andrei Mihai, Bin Zou, Michelle A. Moram (2021). About 335 nm Ultraviolet Emissions Obtained from Simple Metal–Insulator–Semiconductor Light‐Emitting Tunnel Diodes. physica status solidi (a), 218(2), 2000524. (Materials Science, Multidisciplinary = 256/344, Q3) (SCI, impact factor = 4.6).
Patent
1. WO2019234252A1. Method for detecting a tandem repeat. (Georgiou P., Yu L.S., Cardenas, K.M., Fisher M.C., Manzano, J.R., Moser, N.)
2. WO2019234251A1. Method for detecting a single nucleotide polymorphism (SNP) using LAMP and blocking primers. (Georgiou P, Malpartida K, Yu, L.S., Baum J., N. Miscourides, Manzano, J.R.)
Product
1.新冠肺炎檢測試劑-防疫專案核准製造第1096821155號 (專利技轉) (獲歐盟CE, TFDA認證)
2. African swine fever virus 定溫核酸檢測系統 (OIE認證申請中)
Award
1. 2024 中山高醫合作研究優秀獎
2. 2024 優良課程獎
3. 2024 台綜大年輕學者創新研發成果選拔 工程領域 優秀獎 (Excellence Award)
4. 2024 台灣化學感測器科技協會(ACST) 113年度學術獎章之優秀年輕學者論文獎
5. 2024 教育部智慧晶片系統應用創新競賽 銀獎
6. 2023 學術研究團隊績優教師
7. 2023 產學績優獎 (技轉)
8. 2023 院優良導師
9. 2023 優良課程獎
10. 2022 產學績優獎 (產學合作)
11. 2021-2023 新進教師獎勵
Conference
1. Poster presentation. The 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2024)
2. Poster presentation. 2024 APASL Single Topic Conference on MAFLD (2024 APASL STC on MAFLD)
3. Poster presentation. The 19th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (2024 IEEE NEMS)
4. Oral presentation. The 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2023)
5. Poster presentation. The 36th International Conference on Micro Electro Mechanical Systems (MEMS 2023)
6. Ling-Shan Yu. Innovation conference 2019 (The Nation Pan-Disciplinary Conference on Medical and Surgical Technology), 2019.
7. Ling-Shan Yu, Nicolas Moser, Anselm Au, Kenny Malpartida-Cardenas, Sheng-Fan Wang, Yen-Hsu Chen, Jesus Rodriguez-Manzano and Pantelis Georgiou. 22th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2018. (conference talk)
8. Ling-Shan Yu and Michael Tristem. Florey Institute Symposium, Society for General Microbiology, 2014. (2nd prize poster presentation)
9. Ling-Shan Yu and Michael Tristem. Graduate School Summer Symposium, 2012. (1st prize oral presentation)
10. Ling-Shan Yu, Jesus R-Manzano, Nicolas Moser, Sheng-Fan Wang, Yen-Hsu Chen, Alison Holmes, Holmes, P Georgiou. International congress on international diseases 2018. (poster)
11. Kenny M-Cardenas, Nicholas Miscourides, Ling-Shan Yu, Jake Baum, Jesus Rodriguez-Manzano, Pantelis Georgiou. 22th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2018. (poster)
12. Nicolas Moser, Jesus R-Manzano, Ling-Shan Yu, Melpomeni Kalofonou, Sara de Mateo, Xiaoxiang Li, Tor Sverre Lande, Christofer Toumazou and Pantelis Georgiou. IEEE International Symposium on Circuits and Systems, 2017. (Live demonstration and poster)
Invited Talk
1. 2025/1 Annual Meeting of the Physical Society of Taiwan (CRISPR Gene Editing: Transformative Applications in Biomedical Sensing)(Kaohsiung, Taiwan)
2. 2024/3 Smart City Summit & Expo (Topic: Precision Medicine and Diagnostics: Past, Present, and the Future) (Taiwan)
3. 2022/10 International Congress on Infectious Diseases 2022 (Topic: Technology and Innovation in Diagnostics) (Malaysia)
4. 2021/10 台灣積體電路公司
5. 2020/07 National Sun Yat-sen University (Taiwan)
6. 2019/12 National Defense Medical Center (Taiwan)
7. 2019/11 Kaohsiung Medical University (Taiwan)
8. 2019/09 Kaohsiung city government (Taiwan)
9. 2019/08 National Health Research Institute (Taiwan)
10. 2019/05 London Biomedical Society (UK)
11. 2019/03 Innovation Conference UK (UK)
12. 2018/11 Industrial Research Institute (Taiwan)
13. 2018/11 National Health Research Institutes (Taiwan)
14. 2018/07 Linkou Chang Gung Memorial Hospital (Taiwan)
15. 2017/10 Taiwan scientific symposium in London (UK)
Current Projects
1. 110-112年 國科會多年期計畫 (計畫主持人)
2. 110年 教育部高教深耕 智慧生醫感測群 (子計畫主持人)
3. 111-112年 中山高醫計畫 (計畫主持人)
4. 110年 教育部高教深耕 智慧生醫感測群 (子計畫主持人)
5. 111年中山長庚合作計畫 (計畫主持人)
6. 112年 教育部高教深耕 (子計畫主持人)
7. 113-116年 國科會多年期計畫 (計畫主持人)
8. 114年 中山802合作計畫 (計畫主持人)